Anas bin Malik (may Allah be pleased with him) said: The major sins were mentioned in the presence of the Prophet (peace and blessings be upon him). He (peace and blessings be upon him) said: "Associating partners with Allah, killing a soul, disobedience to parents, and false testimony or false speech."
Hadith Referenceالسنن الكبرى للبيهقي / كتاب آداب القاضي / 20381