It is narrated from Sayyiduna Umayr bin Qatadah al-Laythi (may Allah be pleased with him) that the Messenger of Allah (peace and blessings be upon him) said: "The major sins are seven: associating partners with Allah, killing a believing soul, fleeing from battle, consuming usury (riba), consuming the wealth of an orphan, disobeying parents, and violating the sanctity of the Sacred House."
Hadith Referenceالمعجم الكبير للطبراني / باب العين / 14174