It is narrated from Sayyiduna Ibn Umar (may Allah be pleased with them both) that once the Prophet Muhammad (peace and blessings be upon him) came out from the chamber of Sayyidah Aisha (may Allah be pleased with her). He (peace be upon him) pointed towards the east with his hand and said: "The trial will emerge from here, from where the horn of Satan will appear."
Hadith Referenceمسند احمد / مسند المكثرين من الصحابة / 4751
Hadith Gradingحکم دارالسلام:حديث صحيح، م: 2905، وهذا إسناد حسن، عكرمة بن عمار. وإن احتج به مسلم. حسن الحديث، وقد توبع